Nuclear genome size: Are we getting closer?

Ribozymes as therapeutic agents: are we getting closer?

The biology of ribozymes has come far since the initial seminal observations of self-cleaving molecules in Tetrahymena (1) and ribonuclease P (2). With the discovery of the hammerhead ribozyme (3) came the realization that it could be utilized to potentially disrupt the expression of any target gene in trans (i.e., acting from outside the target gene sequence) (4). As different types of catalyt...

Why are we not getting any closer to preventing suicide?

Adaptive significance of play: Are we getting closer?

Life history theory predicts that animals whose activities impose time, energy or survivorship costs at one stage of their lives will subsequently suffer incremental decreases in fitness unless there are compensatory benefits. Play, a widespread activity among juvenile mammals and several orders of birds' appears costly, yet its adaptive significance is poorly understood despite over 15 years o...

Defining remission in psoriatic arthritis: are we getting closer?

Plant functional types : are we getting any closer to the Holy Grail ?

1 Laboratoire d’Ecologie Alpine, CNRS UMR 5553, Université Joseph Fourier, BP 53X, 38041 Grenoble Cedex 9, France. [email protected] 2 Instituto Multidisciplinario de Biología Vegetal (CONICET – UNC) and FCECFyN, Universidad Nacional de Córdoba, Argentina 3 Department of System Ecology, Institute of Ecological Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The N...